The aim of this study was to determine the validity of personality paradigm in study and prediction of entrepreneurship. To this aim, causal-comparative method was used. Data were collected from two groups of entrepreneurs (n=60) and non-entrepreneurs (n=60). The two groups then responded to an standardized questionnaire of Achievement motive, Personal control, Self-esteem, Risk-taking, Innovation, Autonomy, Self-starter, Sense to others, Leadership, Responsibility, Perseverance and Physical energy. The results showed a significant difference between entrepreneurs and non-entrepreneurs regarding Personal control, Achievement motive and Energy. Logistic regression analysis showed that only three variables, of Personal control, Achievement motive and Responsibility are able to predict the entrepreneurship. Basing entrepreneurship research on personality paradigm is confronted with serious challenges. Findings of this research support those researchers' idea concerning “Personality Paradigm Crisis” in inquiry of entrepreneurship.